2013 – 2015
Spintronic point-of-care reader
Problem. Lateral-flow tests are cheap and everywhere, but they only answer yes or no.
Contribution. Designed and microfabricated the magnetoresistive sensor that reads them quantitatively.
Publication ↗Interdisciplinary Scientist · Inventor · Entrepreneur
I turn physical principles into sensing technologies, from a structure a few hundred nanometres across to an instrument that returns a number someone can act on.
Berlin, working across Europe
PhD Biomedical Engineering, Instituto Superior Técnico
14+ years of cleanroom and device work
01 / Between and across disciplines
02 / The structure and the evidence
Nanofabrication means creating and controlling extremely small structures — almost like sculpting materials at the nanoscale. Structures this small interact with light, molecules and other physical fields in ways bulk material does not, and those interactions can become new sensing technologies.
In earlier work I made gold nanodisk arrays whose placement was precise. Their Raman enhancement, however, was insufficient. Instead of returning to lithography, I asked whether those precisely positioned nanodisks could be chemically grown into plasmonic nanostars.
Plasmonics is the study of how light couples to electrons at a metal surface; at sharp tips, light concentrates into a tiny, intense field. That concentration is the basis of SERS — surface-enhanced Raman scattering — which amplifies the faint optical fingerprint of molecules sitting near the metal enough to measure them.
I combined top-down electron-beam patterning with controlled bottom-up gold growth, producing individual nanostars, merged architectures and spike-decorated nanoholes. In simulation, the local field magnitude at the tips was roughly three orders above the equivalent nanodisk. Experimentally, I demonstrated signal detection down to 10−14 molar for 1-naphthalenethiol.
These are electron microscope images of structures far smaller than a human hair. The scale bars show their actual dimensions. Select any image to see it larger, with its caption.
03 / Selected work

04 / Programmes
Across these and earlier programmes I have attracted or co-attracted roughly €532,000 in competitive funding. Figures, identifiers and roles are documented and available on request.

Lithography, deposition, wet chemistry, functionalisation, the fluidics and the electronics around them. The designs that survive are the ones you have had to fabricate yourself, twice.
05 / Devices and prototypes
2013 – 2015
Problem. Lateral-flow tests are cheap and everywhere, but they only answer yes or no.
Contribution. Designed and microfabricated the magnetoresistive sensor that reads them quantitatively.
Publication ↗2016 – 2018
Problem. Circulating tumour cells are vanishingly rare in a blood sample and hard to isolate.
Contribution. Built the three-dimensional flow-focusing microfluidics and the integrated spin-valve sensors that count them.
Publication ↗2019 – 2021
Problem. Terahertz optics — light between microwaves and infrared — lacks tunable, transparent components.
Contribution. Developed cleanroom processes for single-layer graphene devices, from biosensors to field-effect emitters.
Publication ↗2020 – 2025
Problem. Terahertz polarizers are rigid, narrowband or lossy.
Contribution. Invented a fabrication route for a 1 µm double wire grid on flexible transparent polymer, working from 0.1 to 25 THz. Granted European patent EP4024098B1.
Publication ↗2022 – 2025
Problem. SERS substrates are either reproducible or strongly enhancing, rarely both.
Contribution. Combined electron-beam patterning with controlled gold growth to place sharp-tipped nanostars exactly where the light concentrates.
Publication ↗Behind every structure on this page there is a bench, a column of parameters that had to be wrong several times first, and a measurement that either shows the peaks or does not.
06 / nanoSpec Technologies
07 / Engage
08 / Publications and profiles
Tell me what you are building and where it is stuck. If it is a fit, we start with a conversation.
contact@alexandrechicharo.com